Sertificate of Registration GMP/LE/2004/002 Sertificate of Registration ISO 9001:2000 Sertificate of Registration ISO 9001:2000
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information about product

SOLUTION OF GLUCOSE 5 % FOR INJECTIONS

The trading (patented) name of a preparation - the SOLUTION of GLUCOSE 5 % FOR INJECTIONS
The international name -
- SOLUTION of DEXTROSE 5 % FOR INJECTIONS
ATC-CODE - B05BA03

STRUCTURE AND THE FORM OF RELEASE
1 litre of a solution contains
Glucose monohydrate.... 55 g
Other components: water for an injection.
100, 200, 250, 500, 1000, 2000, 3000 ml of solution in plastic PVC containers.


PHARMACOLOGICAL EFFECT
During intravenous administration of the Glucose 5% solution osmotic pressure of blood raises, the fluid current from blood tissues amplifies, processes of a metabolism raise, antitoxic function of a liver improves, cardiac muscle function amplifies, vessels extend, diuresis increases

DOSAGE AND ADMINISTRATION
The dose of glucose is variable and is dependent on individual patient requirements; serum-glucose concentrations may need to be carefully monitored. The maximum rate of glucose utilisation has been estimated to be about 500 to 800 mg/kg per hour.

SIDE-EFFECTS AND CONTRAINDICATIONS
Glucose Intravenous solution for injection (particularly hyperosmotic solutions, which have low pH) may cause local pain, vein irritation, and thrombophlebitis, and tissue necrosis if extravasation occurs. Some of these reactions may be due to degradation of products present after autoclaving or to poor administration technique. Intravenous infusion can lead to the development of fluid and electrolyte disturbances including hyperkalemia, hypomagnesaemia, and hyperphosphataemia. Prolonged administration or rapid infusion of large volumes of iso-osmotic solutions may cause oedema or water intoxication; conversely, prolonged or rapid administration of hyperosmotic solutions may result in dehydration as a consequence of the induced hyperglycaemia. The use of hyperosmotic glucose solutions is contra-indicated in patients with anuria, intracranial or intraspinal haemorrhage, and in delirium tremens where there is dehydration. It has been suggested that glucose solutions should not be used after acute ischaemic strokes as hyperglycaemia has been implicated in increasing cerebral ischaemic brain damage and in impairing recovery. Glucose solutions should not be given through the same infusion set as haemolysis and clumping can occur.

PREGNANCY AND LACTATION
Glucose solutions are commonly employed as hydrating fluids and as vehicles for the administration of other drugs. It has been suggested that if used during labour the glucose load on the mother may lead to fetal hyperglycaemia, hyperinsulinaemia, and acidosis, with subsequent neonatal hypoglycaemia and jaundice. Others have found no evidence of such an effect, especially if the fetus is well-oxygenated, and note that the number of patients included in such reports is often small and the selection criteria not homogeneous.

SPECIAL INDICATIONS
Prolonged administration or rapid infusion of large volumes of iso-osmotic solutions of a hypertonic solution can cause oedema, hypostasis, water intoxication.

STORAGE CONDITIONS AND SHELF LIFE
The preparation should be stored in the dry place protected from light at temperature is not higher 25 oC. Expiry date - 2 years.

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