Sertificate of Registration GMP/LE/2004/002 Sertificate of Registration ISO 9001:2000 Sertificate of Registration ISO 9001:2000
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information about product

RINGER
(Intravenous solution for injection)

The trading (patented) name of preparation - RINGER
The international name
RINGER
ATC-Code B05BB01


THE COMPOSITION AND THE FORM OF RELEASE
1 litre of a solution contains
Sodium Chloride........8.60g
Potassium Chloride....0,30g Calcium Chloride.......0.49g
Other ingredients: water for injection.
100, 250, 400, 500, 1000, 2000, 3000 ml of solution in plastic PVC container.


PHARMACOLOGICAL EFFECT
Solution of RINGER contains balancing mixture of basic/primary cations and is considered as more physiological compared with 0,9% isotonic solution of sodium chloride.
Ringer solution restores water- saline and acid-base balance and is conceredn with the maintenance of fluid composition (fluid deficiency) in the human organism, arising during degeneration or in result of extracellular fluid accumulation in the nidus of extensive burns and during cavitary operations, peritonitis. The preparation raises the alkaline reserve of blood, improves rheological behavior of blood and tissue, increasing the efficacy of hemotransfusion measures during solid blood loss and heavy forms of shock. The preparation possesses desintoxication effect in result of concentration decay of toxic products in blood and diuresis activation.

INDICATIONS FOR ADMINISTRATION
Ringer solution is administered during iso- and hypotensive dehydration and metabolic acidosis, arising in result of continuous diorea and incoercible vomiting, during massive blood loss, shock, extensive burns, during heavy post operation period, toxic poisoning of different etiology. Ringer solution is administered externally as well during different eye, nose, disease mucous coat for washing wounds.


DOSAGE
Ringer solution is prescribed for intravenous administration in drops with controlled rate of 4-10 ml/kg/hr, 500-100ml a day.

SIDE-EFFECTS
Administration of Ringer Solution in large amounts will lead to the development of chloride acidosis, hyperhydration.

CONTRAINDICATION
Ringer Solution is not applied during alkalosis as well as in cases when injection of the solution is contraindicated (brain hemorrhage, tromboembolism, expressed cardio-vascular decompensation, perhydration, hypertensive disease III stage).

PREGNANCY AND LACTATION
Contraindications are not revealed about the administration of the preparation during pregnancy and lactation.

SPECIAL INDICATIONS
Ringer Solution could be prescribed together with haemo transfusion, plasma or plasma substitute transfusion for increasing disintoxication efficiency and contra-dehydration therapy. During prolonged application, especially in big amounts, electrolyte content must be controlled in plasma and urine, diuresis.

STORAGE CONDITIONS AND SHELF LIFE
The preparation should be stored at temperature +10 - +25 oC.Expiry date of the intravenous solution - 2 years.

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